LABORATORY FACILITIES
Research Areas
The Department is actively involved in research by having the distinction of running externally funded R & D projects worth Rs. 10 crores from various Govt. of India agencies such as the Department of Biotechnology, Department of Science & Technology, ICMR, AYUSH, Following are our major research thrusts:
Cancer Reserach Facility |
Phytoanalytical Reasearch Facility |
Microbiology Research Facility |
|---|---|---|
| • Animal cell culture lab with required instruments. Immunoblot of apoptosis marker proteins. | • Extraction of Phytochemicals, Essential Oils, Fragrance and Flavour compounds from Plant material using ETHOS Easy, ETHOS X and SOXHLET extraction | • Antibiotic susceptibility test |
| • Culture of cell lines and cryo preservation. In-vitro toxicity evaluation of the compounds. | • Making Concentration/ powder of extract samples. | • Morphological, Biochemical & molecular characterization of clinical isolates(ESKAPE Pathogens) |
| • Cytotoxicity evaluation of the drugs. Cellular and Tissue imaging. | • Phytochemical profiling using LC-HRMS. | • Screening of medicinal plants, phtochemicals & essential oil for antibacterial activities (Agar well diffusion test) |
| • Study on induction of apoptosis. | • Quantification of Marker compounds using HPLC. | • Determination of biofilm inhibitory activities of medicinal plant extracts, phytochemicals & essential oil against ESKAPE pathogens |
| • Measuring of mitochondrian membrane potential and super oxide radical. | • Bioactive guided fractionation and analysis of grid molecules. | • Evaluation of multidrug resistant efflux pump inhibitory activities |
| • Fluoroscence imaging to study the apoptosis. | • Development of Synthetic derivatives of Lead molecules. | • Determination of synergistic activities of phytochemicals with antibiotics against ESKAPE pathogens. |
Parasite Research Facility |
Plant Tissue Culture Research Facility |
Animal Research Facility |
| • Culture facility of parasites (malaria and filaria). Cryopreservation of parasites | • Sterilization of explant and media preparation. Secondary hardening in green shade net at environmental temperature | • The animal house research have quarantine, behaviour, dissection, haematology, histopathology facilities |
| • Natural, synthetic and antiparasitic drug screening. Gene expression analysis of marker genes using RT_PCR. | • Inoculation of explant. Ex-situ and germplasm conservation in medicinal plant garden. Demonstration plot for tissue culture generated plants | • Experimentation of laboratory animals for toxicological, dermatological, cancer, behaviour(Using ANY-maze), neurological, nephropathological, Bone tissue engineering studies |
| • Cytotoxicity analysis of antiparasitic drug in macrophage cell lines | • Commercial level cultures racks for explants grow and regeneration | • The facility is GLP compliant for conducting toxicological, behavioural, haematological, histopathological and dermatological studies |
| • Phenotypic analysis of parasites before and after treatment | • Primary hardening in green house in controlled environment | • The in-vivo experimentations, animal health and well-being are monitored by trained technicians, experienced researchers and veterinarians. |